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تاریخ عضویت: Mar 2015
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The United States Citizenship and Immigration Service
Texas Service Center
RE: Dr. Genliang (Sample)
Dear Sir/Madam:
I am very delighted to write this letter of reference for Dr. XXX (Sample) in support of the application for permanent residency in the United States under category of a national interest waiver.
My name is XXX and I am the XXX Professor of Chemistry in Department of Chemistry at University of XXX, one of the United Kingdom’s leading universities with an international reputation for its research. I was a Research Associate at XXX University, United State in Professor XXX’s group (1983-1984) and a Visiting Scholar at the University of XXX (1989-1991). I was also a full professor at University of XXX in United Kingdom from XXX to XXX. During my over 30 years career, I have published over 150 papers in internationally reviewed journals and given many presentations at international and national conferences. My research is focused on organic/organometallic synthesis and mechanisms including asymmetric catalysis and synthesis of biologically significant compounds and natural products, spanning from quantum chemistry to electrochemistry. In last few years, we have discovered several novel reactions, using various metallic reagents (Pd, Mo, W, Ru, Ni, Zn, Tl and Hg), accomplished a stereo-selective synthesis of strophanthidin (a cardio-active drug), estrone (a female sexual hormone), and tetrahydrocannabinol (an active constitutent of marihuana), and designed a series of new chiral ligands for asymmetric, transition metal catalyzed reactions and a new electrochemical sensor to differentiate chiral molecules. (may include his major awards and honors)
I do not know Dr. (Sample) personally , but he is well known in the field because of his series of remarkable publications on the research of XXX. In the paper published in the Journal of Organic Chemistry (J. Org. Chem., 2004, 69, 4701-4715), Dr. (Sample) introduced a conceptually new approach to a convergent assembly of highly substituted 1, 2-dihydroquinolines in high levels of regioselectivity from novel azapalladacycles with a metal-bonded stereogenic carbon. He was the first to prepare stable diastereomerically enriched azapalladacycle and oxapalladacycle. Dr. (Sample) was the first to discover a process for generating a highly enriched atropisomer of complex via interaction with solid silica. He proposed a stereoinduction mechanism providing insights relevant to a variety of palladium-catalyzed transformations. He synthesized achiral 1, 2-dihydroquinolines and 2H-1-benzopyrans in excellent enatioselectivity. These results underscore the potential of nonracemic organometallics with a metal-bonded sp3-hybridized stereocenter in asymmetric va(Sample)able organic molecules with biological active properties. This represents an entirely novel powerful approach to asymmetric approach and a breakthrough in organic synthesis. (if you have to use terminology to explain your work, at least try to discuss the importance of your result in layman language)
Dr. (Sample) further impressed me with his innovative work on preparation of contiguously substituted 3, 4-dihydro-2H-1-benzopyrans (J. Org. Chem., 2004, 69, 8266-8279). He discovered a protocol that allows for an efficient amplification of the stereochemical information embedded in the palladium-bonded sp3-hybrididized carbon yielding multiple stereocenters in the organic products. He established a new avenue for a rapid construction of synthetically va(Sample)able and medicinally relevant 2, 3-disubstituted 3, 4-dihydro-2H-1-benzopyrans which could not be achieved via existing methods. The protocol generates two adjacent stereogenic centers and allows for a rapid generation of diverse potentially medicinally relevant benzopyrans for the first time. The results are of interest to a broad community of synthetic and mechanistic organic chemists, considering the growing impact of transition metal-mediated transformations on the practice of manufacturing of pharmaceutical agents.
In a paper published at Organometallics (Organometallics, 2005, 24, 945-961), Dr. (Sample) was the first to synthesize 2, 2, 3, 4-tetrasubstituted 2H-1-benzopyrans and 1, 2-dihydroquinolines in good yields. One of the most impressive achievements is systematic study of the effect of steric properties of auxiliary ligands and substitutents on the formation, stability and reactivity of palladacycles.
Dr. (Sample) synthesized nearly one hundred 2H-1-benzopyrans and 1, 2-dihydro-quinolines which are pharmaceutical significant compounds. Furthermore, thousands of heterocycles such as 2H-1-benzopyrans and 1, 2-dihydroquinolines can be rapidly synthesized using Dr. (Sample)’s method. (is your method currently being used by others in their work? Or if it has been used by the referee himself) This work provides an entire series of 2H-1-benzopyrans and 1, 2-dihydroquinolines and opens door to study biological activities of these compounds by pharmaceutical industries and academic communities. Dr. (Sample)’s research will have a significant impact on the research field of XXX as a whole and will substantially benefit pharmaceutical industries. (being a foreigner, he is not in the proper position to address interest to the U.S. but rather focus on the merit of your work)
Currently, Dr. (Sample) is working as a research associate at Department of Chemistry, XXX University with Professor Kevin Burgess. His current project is to synthesize 3’-O-modified-dNTPs to develop ultrafast sequencing-by-synthesis (SBS) technology for DNA sequencing. Traditional DNA sequencing methods were based on separating DNA fragments by gel electrophoresis, which was extremely labor intensive and expensive. To reduce the cost and increase the throughput of DNA sequencing, as well as to develop smaller, faster sequencing technologies that meet a wider range of needs is a hot topic. Dr. (Sample)’s research will open the door to the next generation of sequencing technologies. Based on his scientific accomplishments and his unparalleled research skills, there is no doubt that he will continue to make unique contributions in DNA sequencing as well as science and technology.
As can be seen from above, Dr. (Sample) has demonstrated his outstanding capability and made significant contributions in his scientific area. During my over 30 years career, I would rank Dr. (Sample) in the top 5% of all researchers I ever encountered. The important research on organic synthesis he has been conducting will certainly benefit the national healthcare and economy of the United States. Considering his past performance, I have confidence that he will continue to contribute to a substantial degree and in a vital ability. I therefore fully support Dr. Genliang (Sample)’s petition for permanent resident status in the United States that will allow him to continue his great career in the U.S. Pleasing contact me if I can be of any additional assistance regarding his petition.
